A toothache is pain in or around a tooth, and the first thing to take for it is usually an over-the-counter pain reliever such as ibuprofen or acetaminophen. Ibuprofen often works better for dental pain because it reduces inflammation as well as pain. These medicines ease symptoms — they do not treat the cause, so a toothache that lasts more than a day or two needs a dentist.
What To Take For Toothache Right Now
Two everyday medicines are the standard first step for dental pain. They work in different ways, and for many people one is a better fit than the other.
Ibuprofen is a nonsteroidal anti-inflammatory drug, or NSAID. It blocks the production of prostaglandins — chemicals the body releases when tissue is injured or inflamed. Because a toothache usually involves inflammation around the tooth or in the pulp, reducing that inflammation often reduces the pain itself. For most adults, ibuprofen is the first choice for a sore tooth.
Acetaminophen relieves pain and fever but does not reduce inflammation. It is a reasonable option for people who cannot take NSAIDs — those with certain stomach, kidney, or bleeding conditions, or those advised against them by a doctor. It is also the usual choice during pregnancy, though anyone pregnant should confirm with their clinician first.
Both are available without a prescription. Follow the dosing on the package label exactly. Do not take more than the label allows, and do not combine multiple products that contain the same ingredient — many cold and flu formulas, for example, contain acetaminophen.
NSAIDs are not right for everyone. People with stomach ulcers, kidney disease, heart failure, or a history of certain bleeding problems are often told to avoid them. If you take a blood thinner or another prescription medicine, check with a pharmacist before adding an NSAID.
Does Ibuprofen or Acetaminophen Work Better for a Toothache?
Ibuprofen tends to work better for dental pain than acetaminophen alone. That is because most toothaches have an inflammatory component, and ibuprofen addresses both pain and inflammation.
Some clinicians suggest alternating or combining the two, since they work through different pathways. This can be effective, but it also raises the chance of a dosing error. If you try it, write down the time of every dose so you do not double up. Never exceed the daily maximum for either medicine.
There is a limit to what any over-the-counter pill can do. If the pain breaks through the medicine, that is a signal the underlying problem is progressing — not a reason to take more.
What About Orajel, Clove Oil, and Other Topical Options?
Topical gels containing benzocaine numb the surface for a short time. They can take the edge off while you wait for an appointment, but they do not reach the source of a deep toothache, and the relief is brief.
Benzocaine gels carry a real caution. They should not be used in children under two, and they should be used sparingly in older children and adults. Overuse can cause a rare but serious blood condition called methemoglobinemia, which reduces the blood’s ability to carry oxygen. This is uncommon, but it is why these products are meant for short-term, limited use — not repeated application throughout the day.
Clove oil is a traditional remedy. Its main compound, eugenol, has mild numbing and antibacterial properties, and some research supports its use for short-term relief. It is not a substitute for dental treatment, and it can irritate gum tissue if used undiluted or too often.
Saltwater rinses do not kill the cause of a toothache, but a warm saltwater rinse can soothe swollen gums and clear debris. It is a comfort measure, not a treatment.
What Not to Put on a Toothache
Some home remedies do more harm than good and can delay real treatment.
- Aspirin held against the gum. This can burn and damage gum tissue. Aspirin is meant to be swallowed, not placed on the gum.
- Whiskey or other alcohol. It does not numb a deep toothache and can irritate already inflamed tissue.
- Ice directly on the tooth. Cold can help swelling on the outside of the face, but direct ice on a sensitive tooth often makes pain worse.
- Antibiotics without a prescription. Antibiotics only help a bacterial infection, and not every toothache is one. Taking them when they are not needed does not help and adds risk.
The most common mistake is treating the pain and skipping the dentist. A toothache that fades on its own can still mean an infection or decay that is quietly getting worse.
When a Toothache Is a Dental Emergency
Most toothaches can wait for a normal appointment. Some cannot.
Seek urgent care if you have facial swelling, swelling that is spreading toward your eye or neck, a fever, trouble swallowing or breathing, or pain that is severe and not controlled by medicine. These signs suggest the infection has moved beyond the tooth, and that is a medical emergency.
A tooth that has been knocked out or badly cracked also needs prompt care. For a knocked-out adult tooth, handling it by the crown — not the root — and getting to a dentist quickly gives the best chance of saving it.
For a routine toothache with no swelling or fever, call your dentist and describe the pain. Sharp pain to hot or cold often points to a cavity or a cracked tooth. A constant, throbbing ache that wakes you at night can point to the pulp — the nerve and blood vessels inside the tooth — being inflamed or infected. Your dentist can tell the difference.
Why a Toothache Needs a Dentist, Not Just a Pill
Pain medicine treats the symptom. The cause stays put.
Most toothaches come from one of a few problems: decay reaching the inner layers of the tooth, an infection in the pulp, a cracked tooth, gum disease, or an impacted wisdom tooth. Each has its own treatment — a filling, a root canal, an extraction, or gum treatment. None of these can be replaced by a painkiller.
There is a useful distinction here. A toothache from a reversible problem, like a small cavity or irritated gum, may settle once the trigger is removed. A toothache from an irreversible one, like an infected pulp, will not heal on its own no matter what you take. The pain may come and go, which fools people into thinking it is gone. It is not.
Left untreated, a pulp infection can spread into the bone and surrounding tissue. That is when a toothache becomes a swelling, and a swelling becomes an emergency. Treating the pain early and seeing a dentist soon is the way to keep a small problem small.
How to Manage the Pain Until Your Appointment
Between now and your dental visit, a few simple steps can keep you more comfortable.
- Take ibuprofen or acetaminophen as directed on the label, and keep track of doses.
- Rinse gently with warm saltwater to soothe gums and clear debris.
- Apply a cold pack to the outside of your cheek for swelling — not directly on the tooth.
- Avoid very hot, very cold, and very sweet foods, which can trigger sharp pain.
- Sleep with your head slightly raised to reduce throbbing.
- Keep the area clean with gentle brushing and flossing.
If the pain is getting worse despite medicine, or if you notice swelling, do not wait for your scheduled visit. Call your dentist and tell them what has changed.
Frequently Asked Questions
What is the best thing to take for a toothache?
Ibuprofen is often the first choice because it reduces both pain and inflammation, which is usually part of a toothache. Acetaminophen is a good alternative for people who cannot take ibuprofen.
Can I take ibuprofen and acetaminophen together for a toothache?
Some clinicians recommend combining or alternating them because they work differently, and this can be effective for dental pain. If you do, track every dose carefully and never exceed the daily maximum on either label.
How long can a toothache wait before I see a dentist?
A mild toothache can usually wait a day or two for a normal appointment, but pain that lasts longer, keeps getting worse, or comes with swelling or fever needs prompt care. Do not rely on pain medicine alone to manage it.
When is a toothache an emergency?
Facial swelling, swelling spreading toward the eye or neck, fever, or trouble swallowing or breathing are emergency signs and need urgent care. A toothache with none of these signs can usually wait for a regular dental visit.

