There are far too many of us suffering chronic inflammation and pain. The cause could be a forgotten childhood back injury, debilitating us as we age. Or, our allergies have worsened over time and now the doctor says it is asthma. Maybe our intestines always bother us. Perhaps arthritis limits our mobility. You name it, any dis-ease produces inflammation (swelling), which is the body’s over-enthusiastic attempt to heal the problem.
With a quick look at inflammation, we learn injury or dysfunction causes leukocytes (white blood cells) to protect the area with inflammation. Leukocyte over-activation has been termed “the enemy within” because it can be detrimental to health when the body over-responds with too much swelling. This can lead to problems with the pancreas, intestines, asthma, trauma, hepatitis, bowel disease, infection, bladder, the spine and joints, etc.
The easy solution is to utilize over the counter Non-steroidal Anti-inflammatories (OTC NSAIDS) such as naproxen sodium, aspirin, ibuprofen (Aleve, Celebrex, Excedrin, Advil, Motrin) until they disrupt digestion and cause ulcers or kidney damage. Relatively benign herbal anti-inflammatories (Boswellin, Bromelain, Curcumin, MSM, Quercetin, Tumeric) work well until they irritate the intestines also. Then, there are the steroids with their dire side effects of increased aggression, liver damage, and heart attack or stroke due to high cholesterol. Some of us have run out of options for decreasing our pain.
Even our pets suffer chronic inflammation. But this might be advantageous for us all. Veterinary pharmaceutical BioVeteria is offering a new class of anti-inflammatories, unrelated to the aforementioned ones (bioveteria.com/leukostat). This hope-inspiring compound is called an Immune Selective Anti- Inflammatory Derivative (ImSAID). BioVeteria Life Sciences and Imulan Bio Therapeutics are offering LeukoSTAT to veterinarians for canine and feline intestinal and oral health. There is currently a study being done on canine atopic dermatitis (allergies), funded by a grant from the American Kennel Club.
While steroids and NSAIDS cause a reduction in immune activity (inflammation), ImSAIDS lessen inflammation itself. An ImSAID is not a synthetic pharmaceutical drug, but a combination of natural amino acids. Amino acids are the organic chemical compounds that form proteins, which are the building blocks for the human body.
While more than 100 amino acids occur in nature, the eight essential (must be ingested) to human health are leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, (and histidine for children). The nonessential (can be made by our bodies) aminos are alanine, arginine, asparagine, aspartic acid, cystine, glutamine, glutamic acid, glycine, ornithine, proline, and serine.
ImSaids are comprised of the amino acids DL-phenylalanine, glutamine and glycine. The specific action of these three amino acids combined appears to be the disruption of leukocyte migration into body tissues, resulting in a lower rate of free radical production and oxidative damage.
By itself, glutamine shortens the healing time for ulcers. Glycine is called the wound healer because of its anti-microbial quality. It is an effective treatment for gastric over-activity and low blood PH. Mixed 50/50 with aspirin it decreases the harmful effects of aspirin. Patients who benefit greatly are postoperative, burn and trauma. Additionally, it increases the absorption of DL-phenylalanine.
Among other things, DL-phenylalanine produces and activates morphine-like hormones called endorphins, which intensify and prolong the body’s own natural pain killing responses to injury and disease. People with chronic pain have lower levels of these endorphins. Since DL phenylalanine can restore normal endorphin levels, it can help the body reduce pain naturally without drugs. Because L-phenylalanine selectively blocks pain, it alleviates long term discomfort while leaving the body’s natural defense mechanisms for injuries intact. This amino acid has been used to treat osteoarthritis, rheumatoid arthritis, low back and joint pain, menstrual cramps, whiplash, and migraines.
DL-phenylalanine offers non-addictive pain relief that becomes more effective over time; it has antidepressant qualities, and can be combined with other medication without adverse interaction. As an integral part of the body, there are no known toxic levels for any of the amino acids.
Relief may occur in a few days, or up to a month. While building up the three-amino acid compound stores in the body, the glycine and glutamine would help prevent and heal any ulcers occurring due to inflammation blockers, until the aminos take full effect.
In time, ImSAIDS may become available for humans, the way these three individual amino acids are currently in our vitamin stores.
JeanAnn is a free-lance writer for health and metaphysics. Her four e-books are available at Amazon.com and Barnes&Noble.com. She also does handwriting analysis and numerology.